Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers. Phone number: 847-491-5510 Office location: Hogan 4-160 wklein@northwestern.edu Yevgenia Kozorovitskiy Soretta and Henry Shapiro Research Professor of Molecular Biology, Associate Professor Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station. Klein and his colleagues have pioneered the concept that memory loss in Alzheimer's Disease is initiated by soluble amyloid beta oligomers, small neurotoxins that target particular synapses and cause their functional and structural degeneration. (4) Cell and molecular mechanisms of memory loss. Targeting Aß oligomers: a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease. Klein, Grant A. Krafft, formerly at Northwestern University's Feinberg School of Medicine and now chief scientific officer at Acumen Pharmaceuticals, Inc., and Caleb E. Finch, professor of biological sciences and gerontology at the University of Southern California, reported the discovery of ADDLs in 1998. (3) Etiology. Search our database of faculty experts who are available to comment on trending news and research. William A. Klein. (5) Structural biology. Therapeutic monoclonal antibodies are nearing clinical trials due to partnering between pharma and Acumen, a biotech built on our past work. Office: Hogan 5-110 Chicago. UCLA Faculty Since 1971. klein@law.ucla.edu. Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, Krafft GA. Chromy BA, Nowak RJ, Lambert MP, Viola KL, Chang L, Velasco PT, Jones BW, Fernandez SJ, Lacor PN, Horowitz P, Finch CE, Krafft GA, Klein WL. William Klein. Name: Klein, William, PhD. Deleterious effects of amyloid β oligomers acting as an extracellular scaffold for mGluR5. Interdisciplinary Biological Sciences PhD Program, Northwestern University Interdepartmental Neuroscience PhD Program (NUIN), Prof William Klein Subproject for Defining native proteoform landscape for amyloid-beta in Alzheimers disease SP0051783, Defining native proteoform landscape for amyloid-beta in Alzheimers disease, Physiological role of naturally-occuring amyloid beta oligomers, Sporadic Alzheimer's Disease modeled with diabetes and high cholesterol in rabbit, A novel, nanoparticle-based molecular MRI probe for early Alzheimer's diagnostics, Antibody fragments as tools for elucidating structure-toxicity relationships and for diagnostic/therapeutic targeting of neurotoxic amyloid oligomers. Professor Klein’s team is helping lead the way toward a molecular basis for the cause, diagnosis, and treatment of Alzheimer’s disease. Dive into details by clicking on the dots. Molecular Biology, PhD, University of California at Los Angeles, Biology, BS, Massachusetts Institute of Technology. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. Year; Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins. Dr. William L. Klein is Professor of Neurobiology in the Weinberg College of Arts and Sciences, Northwestern University. William Klein, PhD Associate Director, Behavioral Research Program William Klein, PhD, was appointed associate director of the Behavioral Research Program (BRP) in August 2009. How neuron damage is triggered by AβOs is being investigated in brain cell culture systems and animal models. Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes. Sort by citations Sort by year Sort by title. Email: wklein@northwestern.edu. (2005). William Klein United States . (2004). Cited by. Learn more about William Klein, Professor, Northwestern University including contact information, career history, news and intelligence. New programs for drug discovery focus on insulin signaling (to block AβO toxicity) and on high throughput screening using nanoscale synaptic membrane mimetics (to obtain compounds that prevent AβO binding to toxin receptors). These include binding to toxin receptors, disrupted trafficking of ion channels and GPCRs, and altered signaling pathways. PNAS. In an early breakthrough study, Prof. Klein’s team introduced the idea that neuron damage leading to AD is instigated by small toxic oligomers of the Aβ peptide. Sort. Monoclonal antibodies that target pathological assemblies of Abeta. (2011). Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. Cited by. Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA. Haes AJ, Chang L, Klein WL, Van Duyne RP. DiChiara T, DiNunno N, Clark J, Bu RL, Cline EN, Rollins MG, Gong Y, Brody DL, Sligar SG, Velasco PT, Viola KL, Klein WL. De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST. Lambert MP, Velasco PT, Chang L, Viola KL, Fernandez S, Lacor PN, Khuon D, Gong Y, Bigio EH, Shaw P, De Felice FG, Krafft GA, Klein WL. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers. Professor of Neurobiology and of Neurology at Northwestern University, Evanston, Illinois. State-of-the-art facilities are being used to discover the molecular organization of synthetic and brain-derived toxic oligomers. Professor of Neurobiology wklein@northwestern.edu (847) 491-5510. Renner M, Lacor PN, Velasco PT, Xu J, Contractor A, Klein WL, Triller A. Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers. Deleterious effects of amyloid β oligomers acting as an extracellular scaffold for mGluR5. Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG. Professional Information. William Klein is a man of two cities: New York and Paris. Alzheimer’s is a $250 billion a year epidemic that will confront virtually all families. Evanston, United States (2017). M eet Our Staff. (2) Diagnostics. San Diego: Oligomers Live Up to Bad Reputation, Part 1 19 Dec 2007; AβOs are excellent targets because of their early role in causing brain damage. Ultrasensitive assays for clinical chemistry are being developed along with unique approaches to brain imaging by PET and molecular MRI. Number of results to display per page. Sinai); Sligar (University of Illinois, Urbana-Champagne). (2015). International journal of molecular sciences. AβO structure is still poorly understood because of the difficulty in characterizing dynamic populations of oligomers in extremely dilute solutions. William L. Klein, PhD Director. Knight EM, Kim SH, Kottwitz JC, Hatami A, Albay R, Suzuki A, Lublin A, Alberini CM, Klein WL, Szabo P, Relkin NR, Ehrlich M, Glabe CG, Gandy S, Steele JW. Harvard, 1952 LL.B. Assistant Professor of Neurobiology yevgenia.kozorovitskiy@northwestern.edu (847) 467-4898. (2016). Together they form a unique fingerprint. Office Phone: 847-491-5510. Harvard, 1957. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Aβ oligomers. Subscribe. Aβ oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. View William Klein’s profile on LinkedIn, the world's largest professional community. Cognitive Neurology Alzheimer's Disease Center (CNADC), Chemistry of Life Processes Institute (CLPI), Center for Molecular Innovation and Drug Discovery (CMIDD), International Institute for Nanotechnology (IIN, Interdepartmental Neuroscience Program (NUIN), Interdisciplinary Biological Sciences Program (IBiS). Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno S, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H. (2013). Computation and Systems Modeling Allied Field, Human Behavior and Cognition Allied Field, Language and Human Communication Allied Field, Class Schedules, Courses, and Registration, Neuroscience Undergraduate Summer Research Grants. Northwestern University and Evanston's Only Daily News Source Since 1881 Información legal: Todas las fotografías se presentan sin intención de lucro y con fines de crítica y/o investigación científica, literaria y/o artística bajo lo previsto en la legislación vigente por conducto de los tratados internacionales en materia de derechos de autor. Molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease. Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease. Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins. Approaches include cryoEM and unique native protein mass spectrometry.Collaborators include Disterhoft, Geula, Meade, Dravid, Luan, Kelleher, Mirkin, and Van Duyne (Northwestern); De Felice and Ferreira (Federal University, Rio de Janeiro); Sebollela (Sao Paolo); Mori and Tomiyama (Osaka); Cuello (McGill); Giacobini (Geneva); Nordberg (Karolinska); Gandy (Mt. Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease, A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies. Northwestern University. Aunque nació en Nueva York y fue educado en el City College de esa ciudad, la actividad de Klein se desarrolla principalmente en Francia. Viola KL, Sbarboro J, Sureka R, De M, Bicca MA, Wang J, Vasavada S, Satpathy S, Wu S, Joshi H, Velasco PT, MacRenaris K, Waters EA, Lu C, Phan J, Lacor P, Prasad P, Dravid VP, Klein WL. William Klein, sin normas ni barreras; a contracorriente Revolucionó la fotografía con su mirada directa, provocativa y cruda. Comenzó como dibujante gráfico e ilustrador de la revista Stars and Stripes. After graduating early from high school, he began studying sociology at the City College of New York. Estudió en el City College de Nueva York, tras lo cual se alistó en el ejército (1945), justo un año después de graduarse. Department: Neurobiology. Alzheimer's and Dementia: Translational Research and Clinical Interventions. ... for Tax Purposes: Sources of a Statutory Solution (with Edward A. Wiegner), 60 Northwestern University Law Review 147-73 (1965). William Klein . These topic labels come from the works of this person. 10 per page; 20 per page; 50 per page; 100 per page; View results as: William KLEIN of Northwestern University, IL (NU) | Read 18 publications | Contact William KLEIN Northwestern University Institute for Neuroscience. Forny-Germano L, Lyra e Silva NM, Batista AF, Brito-Moreira J, Gralle M, Boehnke SE, Coe BC, Lablans A, Marques SA, Martinez AM, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG. Experiments focus on early steps in the toxic mechanism. Dive into the research topics where William L Klein is active. William KleinOmro - William Joseph Klein, age 88, of Omro, received his Angel Wings on Tuesday afternoon, August 20, 2019, after passing away peacefully following a … Klein, W. L. National Institute on Aging. (1) Therapeutics. According to Eliezer Masliah, Director of Neuroscience for the National Institute on Aging, “Progressive accumulation of amyloid beta oligomers has been identified as one of the central toxic events in AD.” Soluble Aβ oligomers, rather than plaques, are now widely regarded as triggering the neuron damage that causes dementia. Verified email at northwestern.edu. Dr. Klein’s research interests fall largely under the areas of self-judgment, risk perception, and risk communication. Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, and Klein WL. (2013). (2015). Our team is helping lead the way toward a molecular basis for the cause, diagnosis, and treatment of Alzheimer’s disease. Website AβO structure is still poorly understood because of the difficulty in characterizing dynamic populations of oligomers in extremely dilute solutions. Synaptic targeting by Alzheimer's-related amyloid β oligomers. Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL. Tras ello se trasladó a Europa, en lo que sería un viaje fundamental para su futura dedicación. The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease. William Klein (b.1928) was born in New York City. William Klein, TOKYO, 1964 (French edition) Tokyo, the fourth book in William Klein’s city series, paints pictures with a visual language which we may be familiar with today, but was daring and practically unique at the time.The French edition opens with a half-page preface by Klein himself, followed by nine pages of introduction, dealing with The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade. Professor of Neurobiology & Physiology Northwestern University Institute for Neuroscience. Toxic Aβ oligomers have provided, moreover, a structural archetype for cytotoxins germane to over two dozen diseases of protein misfolding (including diabetes, Parkinson’s, and prion diseases). Title. Northwestern University. Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis. Yevgenia Kozorovitskiy. William Klein . The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease. (4) Cell and molecular mechanisms of memory loss. (5) Structural biology. His ongoing research is highly collaborative and concerns five areas. Articles Cited by. … Neurobiol Learn Mem, 96(4):529-43. TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys. Therapeutic monoclonal antibodies are nearing clinical trials due to partnering between pharma and Acumen, a biotech built on our past work. Ultrasensitive assays for clinical chemistry are being developed along with unique approaches to brain imaging by PET and molecular MRI. Comments. A mouse model of amyloid β oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. It shows extraordinary sensitivity in detecting certain antigens at extremely low concentrations, now without the use of the polymerase chain reaction (PCR). How neuron damage is triggered by AβOs is being investigated in brain cell culture systems and animal models. (2010). The cause of AβO build up in in late-onset AD is a major unknown. Faculty Director, Northwestern Proteomics n-kelleher@northwestern.edu (847) 467-4362. Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain. Proceedings of the National Academy of Sciences of the United States of America. William Klein. AβOs are excellent targets because of their early role in causing brain damage. 50 per page . (2018). William Lee Klein. William Klein. Georganopoulou DG, Chang L, Nam JM, Thaxton CS, Mufson EJ. Since then, we have collaborated internationally to publish more than 100 papers (with over 16,000 citations) investigating the oligomer hypothesis and how it might lead to mechanism-based diagnostics and therapeutics. Our ongoing research is highly collaborative and concerns five areas. Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. Cellular and Molecular Neuroscience, Research interest(s): Contact Information. Regions(s): (3) Etiology. Our seminal paper (MP Lambert et al, PNAS 95:6448-6453, 1998) has been cited over 3500 times (Google Scholar; see e.g., the review in Nature by Schnabel “Little Proteins, Big Clues,” Nature, 475, S12-14, 2011). We are taking new approaches using non-transgenic models to investigate metabolic factors such as high sugar and fat diets associated with diabetes and hypercholesterolemia. Current and former IBiS students in blue. AβOs provide an optimal target for diagnostics because they appear early in disease and instigate the path to dementia. Carole LaBonne. We are taking new approaches using non-transgenic models to investigate metabolic factors such as high sugar and fat diets associated with diabetes and hypercholesterolemia. The cause of AβO build up in in late-onset AD is a major unknown. Get the latest news delivered to your inbox. Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K. Renner M, Lacor PN, Velasco PT, Xu J, Contractor A. Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP. Sign Up Now (2003). J Neurosci. If you made any changes in Pure these will be visible here soon. Cline EN, Bicca MA, Viola KL, Klein WL. De Felice FG, Vieira MN, Bomfim TR, Decker H, Velasco PT, Lambert MP, Viola KL, Zhao WQ, Ferreira ST. Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL. Title: Professor. This new idea emerged from their discovery that oligomers are potent CNS toxins that rapidly destroy synaptic memory mechanisms. In 1946 he joined the U.S. Army and was stationed in Germany, where he won his first camera in a poker game. 1998 May 26;95(11):6448-6453. Recent external collaboration on country level. William Klein. Richard C. Maxwell Distinguished Professor of Law Emeritus A.B. Ferreira ST, Klein WL. Prof William Klein Subproject for Defining native proteoform landscape for amyloid-beta in Alzheimers disease SP0051783. Approaches include cryoEM and unique native protein mass spectrometry. Neuron, 66(5):739-54. Neurotree: academic genealogy for William Klein, Neurobiology and Physiology, Northwestern University Self-assembly of Abeta(1-42) into globular neurotoxins. Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor. E-mail: david-mclean@northwestern.edu Thomas J. Meade | Bioinorganic coordination chemistry, biological molecular imaging, transcription factor inhibitors, electronic biosensors Phone: (847) 491-2481 The film-maker and photographer was born in the former, but has lived in the latter for more than 60 years, where I meet him at home. AβOs provide an optimal target for diagnostics because they appear early in disease and instigate the path to dementia. William has 1 job listed on their profile. Experiments focus on early steps in the toxic mechanism. (1) Therapeutics. (2014). (2) Diagnostics. Pitt J, Wilcox KC, Tortelli V, Diniz LP, Oliveira MS, Dobbins C, Yu XW, Nandamuri S, Gomes FCA, DiNunno N, Viola KL, De Felice FG, Ferreira ST, Klein WL. View all publications by William L. Klein listed in the National Library of Medicine (PubMed). (2017). Wilcox KC, Marunde MR, Das A, Velasco PT, Kuhns BD, Marty MT, Jiang H, Luan CH, Sligar SG, Klein WL. State-of-the-art facilities are being used to discover the molecular organization of synthetic and brain-derived toxic oligomers. This new idea emerged from our discovery that oligomers are potent CNS toxins that rapidly destroy synaptic memory mechanisms. Alzheimer's disease-affected brain: presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss. (2007). William Klein – The Daily Northwestern A team of Northwestern researchers has developed the first noninvasive method of detecting Alzheimer’s disease in a living animal. He is a member of the university’s Cognitive Neurology and Alzheimer’s Disease Center and formerly was director of Northwestern’s interdepartmental neuroscience program. Abril de 1928 ) es un fotógrafo y director de cine estadounidense of new York in... Brain: presence of oligomeric Aβ ligands ( ADDLs ) suggests a molecular basis for of... Distinguished professor of Law Emeritus A.B MRI in rabbit proteoform landscape for amyloid-beta in Alzheimers disease.. Nonhuman primates derived from Aβ1–42 are potent CNS toxins that rapidly destroy synaptic memory mechanisms York, 19 abril! 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